By Agbai Sharonjoyce
Caffeine is the most widely consumed psychoactive substance in the world—used mostly to boost energy, elevate moods and sharpen alertness.
Caffeine acts as a powerful stimulant by opposing the effects of adenosine, a brain chemical responsible for promoting relaxation and sleepiness. Adenosine is often described as the brain’s “brake pedal.”
When caffeine blocks adenosine, it removes this natural brake, increasing the release of dopamine and norepinephrine, which boost energy and alertness.
This explains the sudden jolt of energy that follows an early-morning cup of coffee. However, while this stimulation can be helpful in moderation, it can also lead to overstimulation if consumed excessively.
Anxiety and agitation
Overconsumption of caffeine can result in symptoms like agitation, restlessness, rapid speech and thought and excitement. The Diagnostic and Statistical Manual of Mental Disorders even recognises several caffeine-related disorders, including caffeine intoxication, caffeine-induced anxiety disorder and caffeine sleep disorder.
Heavy consumption of caffeine can activate the body’s fight-and-flight response, increasing heart rate and stress hormones. This can trigger or worsen anxiety, particularly in individuals already grappling with anxiety disorders like panic attacks.
Caffeine can also impact genetic sensitivity. Some people metabolise caffeine slowly, making them prone to anxiety, irritability and sleep disruption even at low doses.
What’s more, research links excessive intake to mood disturbances and signs of depression, especially in individuals already vulnerable to mental health issues.
In severe cases, caffeine’s effect on dopamine activity—by obstructing adenosine receptors—can exacerbate mental-health conditions like psychosis and schizophrenia. Some studies have shown that patients with a history of consuming excess caffeine display higher levels of anxiety and hostility.
Managing consumption
Because caffeine’s effects vary according to genetics and mental history, moderation is essential. For healthy adults, experts recommend limiting caffeine intake to no more than 400mg with a single dose not exceeding 200mg. Extending this threshold can lead to severe neurological and psychiatric effects.
For individuals who consume caffeine heavily, it is advisable to reduce intake gradually rather than quitting abruptly to avoid withdrawal symptoms like headaches, fatigue and anxiety. This process, referred to as gradual tapering, helps the body adapt smoothly.
Final takeaway
Consumed in moderation, caffeine provides mental benefits like higher alertness, mood boosts, and heightened concentration. However, excessive consumption may overstimulate the brain, leading to anxiety, restlessness and sleep disruption.
Understanding your tolerance level and practising moderation are key to enjoying caffeine without compromising your mental health.
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